What is L-Methylfolate? L-Methylfolate is a more bioavailable form of Folic Acid. By not needing to convert into 5-MTHF, this unique B supplement is able to easily support your body's needs. L-Methylfolate can be found in many forms, such as liquids, powders, pills and chewable tablets. Pure Folic Acid needs to be converted into 5-Methyltetrahydrofolate (5-MTHF) before it can be used in the body. This is where L Methyl folate comes in! How is L-Methylfolate Used? L Methylfolate is an essential B vitamin most commonly used for Folate Deficiency and is known to be included in multivitamin supplements. Folate levels can easily decrease because of various factors including poor diet About Opti-Folate L-Methylfolate Now, our High Potency Activated L-Methyl folate is Non-GMO, gluten free, plus it's specially formulated to provide you with 15 mg per serving.